3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid

3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid - Names and Identifiers

Name	3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid
Synonyms	RARECHEM AL BL 0044 2-TrifluoroMethyl-DL-b-phenylalanine 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid 3-AMINO-3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID Benzenepropanoic acid, b-amino-2-(trifluoromethyl)- 3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID 3-Amino-3-[2-(trifluoromethyl)phenyl]propanoic acid DL-3-Amino-3-(2-trifluoromethylphenyl)propanoic acid benzenepropanoic acid, beta-amino-2-(trifluoromethyl)- DL-3-AMINO-3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID (RS)-3-Amino-3-(2-trifluoromethylphenyl)-propionic acid
CAS	299165-24-5
InChI	InChI=1/C10H10F3NO2/c11-10(12,13)7-4-2-1-3-6(7)8(14)5-9(15)16/h1-4,8H,5,14H2,(H,15,16)

3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid - Physico-chemical Properties

Molecular Formula	C10H10F3NO2
Molar Mass	233.19
Density	1.361g/cm³
Boling Point	308.7°C at 760 mmHg
Flash Point	140.5°C
Vapor Presure	0.000289mmHg at 25°C
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.501

3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid - Introduction

3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid is an organic compound with the chemical formula C10H9F3NO2. The following is a detailed description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid is a colorless crystal or white crystalline powder.
-Solubility: It has low solubility in water, but has good solubility in organic solvents (such as alcohols, ethers and ketones).
-Melting point: approximately 152-155°C.

Use:
3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid has a variety of uses in the chemical and pharmaceutical fields, including:
-As a reagent and catalyst in organic synthesis.
-As a drug intermediate, used in the synthesis of anti-acidic and anti-inflammatory drugs.

Method:
The preparation of 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid can be carried out by the following steps:
1. First, 2-trifluoromethylphenyl methyl ether and sodium cyanide were reacted in the presence of ammonia gas to obtain 2-amino -2-(2-trifluoromethylphenyl) acetonitrile.
2. Then, 2-amino -2-(2-trifluoromethylphenyl) acetonitrile is reacted with hydrogen in the presence of a palladium catalyst, 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid is obtained.

Safety Information:
The specific hazards and safety of 3-Amino-3-(2-(trifluoromethyl)phenyl)propanoic acid need further experiments and studies. When handling and using the compound, it is necessary to follow appropriate laboratory safety practices and use personal protective equipment, such as laboratory gloves and protective glasses.

Last Update：2024-04-09 21:01:54